See which options our team of experts recommend, and which titles are best ignored on the casino floor. In this guide, we will take a closer look at the games with the best odds in a casino, and also at the games with the worst odds. However, this advantage can vary greatly, and knowing what game has the best odds in a casino can make the difference between winning big and going home early. At the core, all games have a house edge, a set of rules that give the casino an advantage over the player. Casinos provide a wide range of gaming options that can use cards, dice, random number generators, or other mechanics to determine the winners.